Kevin K W Wang Selected Research

Calpain

1/2016	Examining the Neural and Astroglial Protective Effects of Cellular Prion Protein Expression and Cell Death Protease Inhibition in Mouse Cerebrocortical Mixed Cultures.
9/2014	Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.
7/2014	Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury.
11/2011	Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
7/2010	αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients.
11/2009	Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathways.
8/2009	Alpha II-spectrin breakdown products serve as novel markers of brain injury severity in a canine model of hypothermic circulatory arrest.
3/2009	Biochemical, structural, and biomarker evidence for calpain-mediated cytoskeletal change after diffuse brain injury uncomplicated by contusion.
3/2008	Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry.
3/2007	Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury.

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Kevin K W Wang Research Topics

Disease

88	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2022 - 02/2002
32	Brain Injuries (Brain Injury) 01/2022 - 10/2007
12	Wounds and Injuries (Trauma) 06/2021 - 01/2006
6	Spinal Cord Injuries (Spinal Cord Injury) 06/2020 - 02/2004
5	Brain Concussion (Cerebral Concussion) 12/2022 - 05/2012
5	Contusions 01/2021 - 01/2004
5	Hypoxia (Hypoxemia) 01/2021 - 01/2007
5	Craniocerebral Trauma (Head Injury) 02/2020 - 01/2009
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 02/2002
5	Stroke (Strokes) 06/2015 - 05/2005
4	Gliosis 01/2018 - 05/2010
4	Necrosis 01/2016 - 09/2006
4	Ischemia 04/2007 - 06/2004
3	Nervous System Diseases (Neurological Disorders) 02/2022 - 05/2014
3	Chronic Traumatic Encephalopathy 01/2022 - 02/2011
3	Inflammation (Inflammations) 01/2022 - 01/2012
3	Neoplasms (Cancer) 06/2020 - 05/2002
3	Parkinsonian Disorders (Parkinsonism) 06/2019 - 05/2008
3	Disease Progression 01/2018 - 10/2010
3	Substance-Related Disorders (Drug Abuse) 01/2010 - 04/2008
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 12/2022 - 01/2017
2	Memory Disorders (Memory Loss) 01/2022 - 01/2017
2	Closed Head Injuries 06/2021 - 01/2019
2	Seizures (Absence Seizure) 01/2021 - 01/2019
2	Tauopathies 01/2019 - 02/2011
2	Diffuse Brain Injuries (Diffuse Brain Injury) 01/2018 - 03/2009
2	Blast Injuries 11/2013 - 06/2013
2	Hypothermia 03/2013 - 01/2013
2	Alzheimer Disease (Alzheimer's Disease) 02/2011 - 05/2005
2	Mental Disorders (Mental Disorder) 01/2009 - 04/2008
2	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 10/2007 - 04/2007
2	Neuroblastoma 11/2004 - 05/2003
2	Pheochromocytoma 12/2003 - 09/2002
1	Atrophy 01/2022
1	Hemorrhage 06/2021
1	Hemorrhagic Shock 01/2021
1	Post-Traumatic Epilepsy (Epilepsy, Post Traumatic) 01/2021
1	Coma (Comas) 12/2020

Drug/Important Bio-Agent (IBA)

65	Biomarkers (Surrogate Marker)IBA 12/2022 - 06/2005
34	Proteins (Proteins, Gene)FDA Link 12/2022 - 02/2004
19	Glial Fibrillary Acidic ProteinIBA 12/2022 - 05/2010
18	SpectrinIBA 01/2021 - 12/2005
16	Pharmaceutical PreparationsIBA 01/2021 - 12/2006
16	CalpainIBA 01/2016 - 12/2005
9	Caspase 3 (Caspase-3)IBA 01/2018 - 12/2005
8	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2022 - 12/2005
7	Peptide Hydrolases (Proteases)FDA Link 06/2020 - 05/2005
6	Ubiquitin CIBA 01/2021 - 02/2010
5	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 01/2019 - 01/2010
5	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2018 - 05/2008
4	UbiquitinIBA 01/2021 - 05/2008
4	Neuroprotective AgentsIBA 03/2016 - 04/2007
4	CaspasesIBA 01/2016 - 05/2003
4	EnzymesIBA 01/2016 - 06/2011
3	C-Reactive ProteinIBA 12/2022 - 09/2011
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2021 - 03/2016
3	AutoantibodiesIBA 01/2021 - 01/2014
3	Cathepsin BIBA 01/2020 - 02/2004
3	Myelin Basic ProteinIBA 01/2018 - 08/2006
3	ProteomeIBA 01/2017 - 03/2006
3	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 01/2010 - 09/2007
2	CytokinesIBA 01/2022 - 01/2022
2	poly(vinylpyrrolidone-co-vinyl-acetate)IBA 01/2021 - 01/2018
2	Glyburide (Glibenclamide)FDA LinkGeneric 01/2021 - 01/2018
2	Calcium-Binding ProteinsIBA 12/2020 - 01/2018
2	Cysteine Proteases (Cysteine Protease)IBA 01/2020 - 02/2004
2	salicylhydroxamic acid (SHAM)IBA 01/2019 - 02/2004
2	Phosphotransferases (Kinase)IBA 01/2019 - 01/2019
2	Therapeutic UsesIBA 01/2018 - 01/2013
2	Levetiracetam (Keppra)FDA LinkGeneric 01/2018 - 03/2016
2	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2017 - 01/2016
2	CatecholaminesIBA 01/2016 - 06/2013
2	Dopamine (Intropin)FDA LinkGeneric 06/2013 - 12/2003
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 09/2011 - 09/2006
2	Cocaine (Cocaine HCl)IBA 01/2010 - 01/2009
2	dicesium N-succinimidyl 3- (undecahydrododecaboranyldithio)propionateIBA 11/2009 - 01/2009
2	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2009 - 11/2004
2	CalciumIBA 01/2009 - 11/2004
2	Glutamic Acid (Glutamate)FDA Link 04/2007 - 01/2007
2	SurvivinIBA 11/2005 - 09/2004
2	Messenger RNA (mRNA)IBA 05/2005 - 02/2004
2	Protein Glutamine gamma Glutamyltransferase 2IBA 06/2004 - 02/2002
2	Amphetamine (Amfetamine)FDA LinkGeneric 12/2003 - 09/2002
1	Peptides (Polypeptides)IBA 02/2022
1	NeurograninIBA 02/2022
1	VimentinIBA 02/2022
1	ChemokinesIBA 01/2022
1	TESIBA 01/2022
1	Heparin (Liquaemin)FDA LinkGeneric 06/2021
1	HMGB1 Protein (HMG1)IBA 01/2021
1	HydrolasesIBA 01/2021
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2021
1	Tumor Necrosis Factor Ligand Superfamily Member 14IBA 01/2021
1	LipidsIBA 12/2019
1	EmulsionsIBA 12/2019
1	Levodopa (L Dopa)FDA LinkGeneric 06/2019

Therapy/Procedure

18	Therapeutics 02/2022 - 08/2005
5	Precision Medicine 01/2021 - 01/2010
2	Craniotomy 01/2020 - 01/2013
2	Induced Hypothermia 03/2013 - 01/2013